The USRA Aviation Data Science Lab is conducting research and education to advance national capabilities for applying machine learning and other data science techniques to grand challenges in aviation systems such as Urban Air Mobility. In collaboration with NASA’s Ames Research Center, academia and industry, a focus of the lab is on developing curriculum on aviation data sciences with academia for workforce development, as well as research and development to advance national needs for improved mobility of people and goods. Advances in Artificial Intelligence and Data Science are already positively impacting air transportation of goods and people, and have the promise for increased impact as the number of air vehicles grows exponentially with unmanned aerial systems and the amount of data grows in civil aviation with connected aircraft.